Composing @Play

Modern college students traverse the boundaries of traditional literacy daily. Maturing alongside Web 2.0 and multimodal social networking, these young people tweet, blog, email, film, photograph, illustrate, hyperlink, and compose their lives regardless of formal instruction. Therefore rhetorically analyzing a student\u27s recreational play with image, video, audio, and oral mediums often proves helpful for writing instructors who wish to better mentor and engage the communicative capacities of those born in the late 20th century and after. Yet few educators have actively pursued this line of inquiry over the last couple of decades. Many continue to favor traditional pairing of academic discourse with alphabetic literacy, logic, and media. Unfortunately, this means academic writing in general, and composition studies in particular, grow increasingly obsolete when facing a generation of young people whose nearly native relationship with new media encourages them to transcend the computer screen and channel their digital fluencies toward (re)composing physical reality. Few incidents illustrate the stakes and values of such conditions more clearly than the recent case of the Barefoot Bandit-a seemingly average teenager from Washington State, who made international headlines for his two-year joyride with reality: stealing vehicles, flying planes, evading police, robbing businesses, and hijacking the hearts of his peers. Armed with little more than an Apple laptop and iPod, Internet access allegedly sponsored the Barefoot Bandit\u27s specialized education in breaking the law. Not wishing to validate his unlawful behavior, my research awards importance rather to the hardly exceptional nature of his personal technologies, literacies, and motivations. In an age where any given American teenager may access the same technological resources, the lasting influence of formal education seems questionable when facing a digitally literate generation of perpetual bandits. By rhetorically analyzing the discursive conditions instigating young people to (re)compose their own educations, the following study elucidates and tests a new interpretive model for educators to use in assessing and challenging the abilities of a generation whose multifaceted literacies seem best nourished by banditry. For writing education to retain relevancy, composition pedagogues must look to the fringes of modern composing practices-where students (at least digitally) know and compose valuable non-institutional texts for diverse audiences

Barriers to Enterprise Development in the Caribbean

Caribbean economies have suffered from stagnant growth since the 1990s. This can be a feature of small developing economies and is a major concern for policy-makers. In this paper, we examine establishment-level data to gain a better understanding of the factors that constrain the growth of businesses in the region. In addition to documenting broad differences in obstacles to business within and across the region, we particularly focus on the main obstacles affecting small and medium-sized firms. The econometric analysis highlights three main barriers at a regional level: an inadequately educated workforce; access to finance; and crime, theft and disorder. However, there are variations at the country level and the analysis indicates clusters of countries that experience obstacles to similar degrees. The paper concludes with recommendations for alleviating the constraints to enterprise development and in stimulating economic growth

OER: A Field Guide for Academic Librarians

We intend this book to act as a guide writ large for would-be champions of OER, that anyone—called to action by the example set by our chapter authors—might serve as guides themselves. The following chapters tap into the deep experience of practitioners who represent a meaningful cross section of higher education institutions in North America. It is our hope that the examples and discussions presented by our authors will facilitate connections among practitioners, foster the development of best practices for OER adoption and creation, and more importantly, lay a foundation for novel, educational excellence.https://scholarworks.boisestate.edu/fac_books/1510/thumbnail.jp

Enterprise and entrepreneurship in the Caribbean region: introduction to the special issue

Entrepreneurship as a pseudo-discipline has matured to the point where it has begun to question the myths which have developed around it. As a panacea for the development ills of capitalism, studies have spanned various ideological and methodological viewpoints. Spatially, entrepreneurship studies have grown to include countries of the Global South and emerging economies, particularly those of Eastern Europe. This special issue extends this reach to the small developing states of the Caribbean and particularly those with a British colonial legacy rooted in the remnants of the plantation economy. The commencement of political independence in the 1960s has not resulted in any significant economic independence for the region as it remains dependent on foreign investment, whilst its key sectors remain subject to the volatility of the economies of the global north. The papers in this special issue identify domestic and enterprise level constraints to the development of entrepreneurship in the region. This Introduction places these, mostly micro-level studies, in a wider context, concluding that policy-makers need to better understand the concept of entrepreneurship and its role in achieving developmental goals. Our challenging recommendation is that those formulating and delivering these policies and practices should do so with an entrepreneurial mind-set

The internationalisation of the small-to-medium sized enterprise (SME): a critical realist approach

The Small- to Medium- Sized Enterprise (SME) has attracted the attention of researchers and governments because of the increasingly important role it is playing in national and international economies. The current research is directed towards understanding the internationalisation of this important economic unit, specifically the internationalisation of SMEs in the East Midlands region of the United Kingdom. The research adopts a critical realist philosophy, used by researchers to explain the decision-making process, and applies it in a different context to provide insights into the internationalisation process of the SME. A critical realist approach is used as it enables an understanding of the roles of structures and the contingent environment in facilitating differing levels of SME internationalisation. These are factors that are believed to operate at a level below that of the observable. The study adopts a mixed methodology (a questionnaire survey and two company case studies) that identifies three main issues, including, the international orientation of the industry, previous international experience of management, and the age of the firm. The survey also identified two other issues, perceptions of competition levels, and technology. All of these factors heavily influenced the differing internationalisation levels seen. The two case study companies were used to illustrate the issues at a real level, highlighting the effect of the structures of the capitalist mode of production and the supply chain. The roles of these structures were shown as not deterministic, as the affect of structure was only exhibited under particular contingent conditions in the external and internal environment

Cultivating Textbook Alternatives From the Ground Up: One Public University’s Sustainable Model for Open and Alternative Educational Resource Proliferation

This note from the field reviews the sustainability of an institution-wide program for adopting and adapting open and alternative educational resources (OAER) at Kansas State University (K-State). Developed in consult of open textbook initiatives at other institutions and modified around the needs and expectations of K-State students and faculty, this initiative proposes a sustainable means of incentivizing faculty participation via institutional support, encouraging the creation and maintenance of OAER through recurring funding, promoting innovative realizations of “educational resources” beyond traditional textbooks, and rallying faculty participation in adopting increasingly open textbook alternatives. The history and resulting structure of the initiative raise certain recommendations for how public universities may sustainably offset student textbook costs while also empowering the pedagogies of educators via a more methodical approach to adopting open materials

Epigenetic Age Acceleration in Frontotemporal Lobar Degeneration: A Comprehensive Analysis in the Blood and Brain

Frontotemporal lobar degeneration (FTLD) includes a heterogeneous group of disorders pathologically characterized by the degeneration of the frontal and temporal lobes. In addition to major genetic contributors of FTLD such as mutations in MAPT, GRN, and C9orf72, recent work has identified several epigenetic modifications including significant differential DNA methylation in DLX1, and OTUD4 loci. As aging remains one of the major risk factors for FTLD, we investigated the presence of accelerated epigenetic aging in FTLD compared to controls. We calculated epigenetic age in both peripheral blood and brain tissues of multiple FTLD subtypes using several DNA methylation clocks, i.e., DNAmClockMulti, DNAmClockHannum, DNAmClockCortical, GrimAge, and PhenoAge, and determined age acceleration and its association with different cellular proportions and clinical traits. Significant epigenetic age acceleration was observed in the peripheral blood of both frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) patients compared to controls with DNAmClockHannum, even after accounting for confounding factors. A similar trend was observed with both DNAmClockMulti and DNAmClockCortical in post-mortem frontal cortex tissue of PSP patients and in FTLD cases harboring GRN mutations. Our findings support that increased epigenetic age acceleration in the peripheral blood could be an indicator for PSP and to a smaller extent, FTD

Boise State Open Educational Resources Staff Training

Join colleagues from the Library, eCampus, Learning Technology Solutions and the IDEA Shop for a morning of learning about OER. Goals include: 1) Participants will learn about OER and how we can help support faculty interested in adopting OER. 2) Participants will meet each other, learn what we do in our respective departments and how we can work together

Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue

Aims: Epigenetic clocks are widely applied as surrogates for biological age in different tissues and/or diseases, including several neurodegenerative diseases. Despite white matter (WM) changes often being observed in neurodegenerative diseases, no study has investigated epigenetic ageing in white matter. Methods: We analysed the performances of two DNA methylation-based clocks, DNAmClockMulti and DNAmClockCortical, in post-mortem WM tissue from multiple subcortical regions and the cerebellum, and in oligodendrocyte-enriched nuclei. We also examined epigenetic ageing in control and multiple system atrophy (MSA) (WM and mixed WM and grey matter), as MSA is a neurodegenerative disease comprising pronounced WM changes and α-synuclein aggregates in oligodendrocytes. Results: Estimated DNA methylation (DNAm) ages showed strong correlations with chronological ages, even in WM (e.g., DNAmClockCortical, r = [0.80–0.97], p  0.31, p < 0.05), and similar trends were obtained with DNAmClockMulti. Although increased age acceleration was observed in MSA compared with controls, no significant differences were detected upon adjustment for possible confounders (e.g., cell-type proportions). Conclusions: Our findings show that oligodendrocyte proportions positively influence epigenetic age acceleration across brain regions and highlight the need to further investigate this in ageing and neurodegeneration

Clinical considerations in early-onset cerebral amyloid angiopathy

Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease associated with brain haemorrhage and cognitive change. The commonest form, sporadic amyloid-beta CAA, usually affects people in mid- to later life. However, early-onset forms, though uncommon, are increasingly recognised and may result from genetic or iatrogenic causes that warrant specific and focussed investigation and management. In this review, we firstly describe the causes of early-onset CAA, including monogenic causes of amyloid-beta CAA (APP missense mutations and copy number variants; mutations of PSEN1 and PSEN2) and non-amyloid-beta CAA (associated with ITM2B, CST3, GSN, PRNP and TTR mutations), and other unusual sporadic and acquired causes including the newly-recognised iatrogenic subtype. We then provide a structured approach for investigating early-onset CAA, and highlight important management considerations. Improving awareness of these unusual forms of CAA amongst healthcare professionals is essential for facilitating their prompt diagnosis, and an understanding of their underlying pathophysiology may have implications for more common, late-onset, forms of the disease